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KMID : 0388220120190030138
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Journal of the Korean Rheumatism Association
2012 Volume.19 No. 3 p.138 ~ p.146
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Prevalence and Clinical Features of Hyperuricemia in Gwangju and Jeonnam Territories
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Hong Su-Jin
Kim Yun-Sung
Kim Hyun-Sook
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Abstract
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Objective: This study was designed to identify the prevalence and clinical features of hyperuricemia in Gwangju and Jeonnam territories.
Methods: We enrolled 2309 participants who underwent health examinations at Chosun University Hospital from January 2008 to June 2010. All participants were free from gout, diabetes, hypertension, rheumatoid arthritis, dyslipidemia, cerebral infarction, cardiovascular disease, cancer, asthma, and autoimmune disease. Hyperuricemia was defined as ≥7 mg/dL in males and ≥6 mg/dL in females. Metabolic syndrome was defined using the International Diabetes Federation (IDF) criteria, which were revised in 2005. Clinical profiles were investigated, including age, waist circumference (WC), body- mass index (BMI), fasting glucose, HbA1c, triglycerides, total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), blood pressure (BP), high-sensitivity-C-reactive protein (hs-CRP), homocysteine, fibrinogen, total bilirubin, gamma-glutamyl transferase (r-GT), aspartate aminotransferase/alanine aminotransferase (AST/ ALT), alcohol consumption, smoking and exercise.
Results: The overall prevalence of hyperuricemia was 9.8% among our study. The condition was more common in males than in females (15.0% vs 4.1%). Uric acid concentration was correlated with WC, BMI, BP, triglycerides, total cholesterol, hs-CRP, and r-GT (p<0.05). Additionally, among males, uric acid concentration was correlated with WC. The prevalence of metabolic syndrome increased when uric acid concentration increased. Males with hyperuricemia had 2.3-fold higher risk of metabolic syndrome (odds ratio (OR)=2.33). Female with hyperuricemia had 2.8-fold higher risk of metabolic syndrome (OR=2.78) as compared to those without hyperuricemia.
Conclusion: The overall incidence of hyperuricemia was 9.8%. The prevalence of metabolic syndrome increased along with increases in uric acid concentration. Hyperuricemia may be positive predictive factor for metabolic syndrome and also may be risk factor in cardiovascular morbidity.
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KEYWORD
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Hyperuricemia, Metabolic syndrome
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